| 发明名称 |
PHARMACEUTICAL DOSAGE FORM CAPABLE OF MAINTAINING STABLE DISSOLUTION PROFILE UPON STORAGE |
| 摘要 |
The present invention provides a pharmaceutical dosage form comprising a fill material sealed in a gelatin capsule; the fill material comprises (a) a selective COX-2 inhibitory drug of low water solubility, and (b) a primary or secondary amine compound in an amount sufficient to inhibit cross-linking of gelatin in said gelatin capsule upon storage of the dosage form in a closed container maintained at 40 °C and 75 % relative humidity for a period of 6 months. |
| 申请公布号 |
WO2004010973(A2) |
申请公布日期 |
2004.02.05 |
| 申请号 |
WO2003US24043 |
申请日期 |
2003.07.31 |
| 申请人 |
PHARMACIA CORPORATION;GAO, PING;BAUER, JULIANE, M.;HE, XIAORONG |
发明人 |
GAO, PING;BAUER, JULIANE, M.;HE, XIAORONG |
| 分类号 |
A61K9/107;A61K9/48;A61K9/66;A61K31/132;A61K31/133;A61K31/18;A61K31/197;A61K31/365;A61K31/415;A61K31/4164;A61K31/42;A61K31/495;A61K31/50;A61K31/635;A61K45/00;A61K47/02;A61K47/04;A61K47/10;A61K47/12;A61K47/14;A61K47/16;A61K47/18;A61K47/20;A61K47/22;A61K47/34;A61K47/36;A61K47/42;A61P1/04;A61P1/16;A61P3/10;A61P5/14;A61P9/00;A61P9/10;A61P11/00;A61P11/06;A61P15/00;A61P15/06;A61P17/00;A61P17/02;A61P17/06;A61P17/10;A61P17/16;A61P19/02;A61P21/00;A61P21/04;A61P25/04;A61P25/06;A61P25/28;A61P25/32;A61P27/02;A61P29/00;A61P31/12;A61P31/18;A61P33/00;A61P35/00;A61P43/00 |
主分类号 |
A61K9/107 |
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