PYRROLOQUINOLINE QUINONE DRUGS AS A NEUROPROTECTANT AND METHODS OF USE THEREOF

摘要

The invention includes compositions comprising substantially purified pyrroloquinoline quinone, that are useful in methods for the treatment and prevention of acute and chronic neurological injury caused by peroxynitrite. The invention also includes methods for the treatment and prevention of neurological injury comprising contacting a composition of the invention with a human patient. In embodiments of the invention, pyrroloquinoline quinone is provided prior to formation of peroxynitrite.