Bcr-Abl directed compositions and uses for inhibiting Philadelphia chromosome stimulated cell growth

摘要

Compositions comprising or encoding one or more peptides that inhibit the Bcr-Abl oncoprotein and that bind to molecules involved in Bcr-Abl function are disclosed. The peptides and polypeptides inhibit the growth of, and induce cell death of, Philadelphia chromosome-positive leukemia cells expressing the Bcr-Abl oncoprotein. Methods for treating leukemias (e.g., CML, ALL and AML), including autologous bone marrow transplant therapy, using the peptide and polypeptide compositions of the invention are also provided.