| 摘要 |
Compounds of formula (I) cyclo ~NX1-R1-CO-NX2-R2-CO-NX3-R3-CO-NX4-CO-NX5-R5- CO~, wherein at least one x-fluoroalkylated amino acid is present, are inhibitors of integrins, particularly those belonging to the .alpha.v.beta.3 and .alpha.v.beta.5 family, and thus are useful as medicaments, particularly for the treatment of the underlying diseases responsible for abnormal angiogenesis, such as retinopathy, acute kidney failure, osteoporosis and metastases. The compounds described herein are also useful as diagnostic agents, when appropriately labelled, especially for the detection and locati on of small tumour masses and arterial occlusion events.
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