发明名称 |
POLYPEPTIDE CLEAVAGE PROCESS |
摘要 |
The invention provides a palladium-promoted hydrolytic polypeptide cleavage process which selectively cleaves the polypeptide at a Cys-His cleavage site comprising solubilizing the polypeptide in a reaction mixture comprised of a palladium promotor dissolved in a high- concentration formic acid, wherein the concentration of the formic acid in the reaction mixture is between about 1 to about 22 molar. |
申请公布号 |
WO2004011599(A2) |
申请公布日期 |
2004.02.05 |
申请号 |
WO2003US16647 |
申请日期 |
2003.05.23 |
申请人 |
RESTORAGEN INC.;SEO, JIN SEOG;HOLMQUIST, BARTON |
发明人 |
SEO, JIN SEOG;HOLMQUIST, BARTON |
分类号 |
C07F15/00;C07K1/12;C07K7/06;C07K14/60;C07K14/635;C12P21/06 |
主分类号 |
C07F15/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|