QUINOLINE DERIVATIVES AND THEIR USE AS 5-HT6 LIGANDS

摘要

The present invention relates to quinoline compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R<1> and R<2> independently represent hydrogen or C1-6 alkyl or R<1> is linked to R<2> to form a group (CH2)2, (CH2)3 or (CH2)4; R<3>, R<4> and R<5> independently represent hydrogen, halogen, cyano, -CF3, -CF3O, C1-6 alkyl, C1-6 alkoxy, C1-6 alkanoyl or a group -CONR<6>R<7>; m represents an integer from 1 to 4, such that when m is an integer greater than 1, two R<2> groups may instead be linked to form a group CH2, (CH2)2 or (CH2)3; n represents an integer from 1 to 3; p represents 1 or 2; A represents a group -Ar<1> or -Ar<2>Ar<3>; Ar<1>, Ar<2> and Ar<3> independently represent and aryl group or a heteroaryl group, both of which may be optionally substituted by one or more substituents having pharmacological activity, to processes for their preparation, to compositions containing them and to their use in the treatment of CNS and other disorders.