发明名称 |
Process for producing optically active imidazole compounds, intermediates for synthesizing the same, and process for producing the same |
摘要 |
The present invention provides a method for producing an optically active 4-Ä alpha -hydroxy-5-(1-imidazolyl)-2-methylbenzylÜ-3,5-dimethylbenzoic acid or a pharmaceutically acceptable salt thereof, which includes subjecting a compound of the formula (I) <CHEM> wherein each symbol in the formula is as defined in the specification, to optical resolution by fractional crystallization to give an optically active compound thereof and subjecting the compound to hydrolysis reaction. According to this method, a resolution method useful for industrial large-scale production of the optically active compound of 4-Ä alpha -hydroxy-5-(1-imidazolyl)-2-methylbenzylÜ-3,5-dimethylbenzoic acid, which is useful as a thromboxane synthetase inhibitor and an agent for the prophylaxis and treatment of diabetic complications, can be obtained. |
申请公布号 |
EP1378507(A3) |
申请公布日期 |
2004.02.04 |
申请号 |
EP20030022830 |
申请日期 |
1998.01.14 |
申请人 |
MITSUBISHI PHARMA CORPORATION |
发明人 |
KAWASAKI, KAZUYUKI;KOBAYASHI, HARUHITO;EHARA, SYUJI;SATO, HIDEAKI |
分类号 |
A61K31/415;A61P3/10;A61P43/00;C07D233/58;C07D233/60;C07D521/00 |
主分类号 |
A61K31/415 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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