| 摘要 |
<p>The present invention relates to derivates of an insulinotropic peptide Exendin-4 and pharmaceutically acceptable salts produced thereof, which are useful for the treatment of type II diabetes. Exendin-4 has the chemical structure as shown below: <IMAGE> In which: X represents Arg, Leu or Ile, Y represents His, Arg or Lys and Z represents Arg-OH, -OH, - NH2 or Lys-OH. <??>The derivates of this invention may be prepared by synthetic chemical means, and more easily, by the recombinant techniques, which makes it possible to commercial production.</p> |
