发明名称 Intermediates for the preparation of anti-thrombotic 4H-cyclopenta-1,3-dioxol derivatives
摘要 The invention provides the compounds: (1S-cis)-2-ÄÄ4-ÄÄ6-Chloro-5-nitro-2-Ä(3,3,3-trifluoropropyl)thioÜ-4-pyrimidinylÜaminoÜ-2-cyclopenten-1-ylÜoxyÜ-acetic acid, ethyl ester; Ä3aS-(3a alpha ,4 alpha ,6 alpha ,6a alpha )Ü-ÄTetrahydro-6-hydroxy-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ylÜ-carbamic acid, phenylmethyl ester; Ä3aS-(3a alpha ,4 alpha ,6 alpha ,6a alpha )Ü-Ä2,2-Dimethyl-6-(2-hydroxyethoxy)-tetrahydro-4H-cyclopenta-1,3-dioxol-4-ylÜ-carbamic acid, phenylmethyl ester; Ä3aR-(3a alpha ,4 alpha ,6 alpha ,6a alpha )Ü-2-ÄÄ6-Amino-2,2-dimethyl-tetrahydro-4H-cyclopenta-1,3-dioxol-4-ylÜoxyÜ-ethanol; 2-(Butylthio)-4,6-dichloropyrimidine-5-amine; Ä3aR-(3a alpha ,4 alpha ,6 alpha ,6a alpha )Ü-2-ÄÄ6-ÄÄ5-Amino-2-(butylthio)-6-chloro-pyrimidin-4-ylÜaminoÜ-tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ylÜoxyÜethanol; Ä3aR-(3a alpha ,4 alpha ,6 alpha ,6a alpha )Ü-6-ÄÄ6-Chloro-5-nitro-2-(propylthio)-pyrimidin-4-ylÜaminoÜ-tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol.
申请公布号 EP1386921(A1) 申请公布日期 2004.02.04
申请号 EP20030025536 申请日期 1999.12.02
申请人 ASTRAZENECA AB 发明人 HARDERN, DAVID;INGALL, ANTHONY;SPRINGTHORPE, BRIAN;WILLIS, PAUL;GUILE, SIMON
分类号 C07D317/44;A61K;A61K31/519;A61P;A61P9/00;A61P9/10;C07C211/40;C07D;C07D239/48;C07D487/04;(IPC1-7):C07D405/12;C07D239/46 主分类号 C07D317/44
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