| 发明名称 |
Diarylalkyl cyclic diamine derivatives as chemokine receptor antagonists |
| 摘要 |
Cyclic diamines of formula (I) or their pharmacologically acceptable acid addition salts, and their medical applications are described. These compounds inhibit the action of chemokines such as MIP-1a and/or MCP-1 on target cells, and are useful as a therapeutic drug and/or preventative drug in diseases, such as atherosclerosis, rheumatoid arthritis, and the like where blood monocytes and lymphocytes infiltrate into tissue.
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| 申请公布号 |
US6686353(B1) |
申请公布日期 |
2004.02.03 |
| 申请号 |
US19990180994 |
申请日期 |
1999.07.15 |
| 申请人 |
TEIJIN INTELLECTUAL PROPERTY CENTER LIMITED;COMBICHEM, INC. |
发明人 |
SHIOTA TATSUKI;YAMAGAMI SHINSUKE;KATAOKA KENICHIRO;ENDO NORIAKI;TANAKA HIROKO;BARNUM DOUG;GREENE JONATHAN;MOREE WILNA;WEINHOUSE MICHELE RAMIREZ;TARBY CHRISTINE M. |
| 分类号 |
C07D295/06;A61K31/4184;A61K31/42;A61K31/4245;A61K31/495;A61K31/496;A61K31/506;A61K31/522;A61K31/535;A61K31/541;A61P1/04;A61P9/10;A61P11/06;A61P17/06;A61P19/00;A61P19/02;A61P29/00;A61P43/00;C07D207/335;C07D209/14;C07D209/48;C07D213/38;C07D213/81;C07D215/12;C07D233/32;C07D235/14;C07D235/26;C07D239/54;C07D243/08;C07D261/08;C07D265/22;C07D271/06;C07D285/08;C07D295/08;C07D295/14;C07D295/16;C07D307/52;C07D311/18;C07D317/28;C07D317/58;C07D333/20;C07D333/38;C07D333/68;C07D401/06;C07D403/06;C07D405/06;C07D405/10;C07D405/14;C07D409/06;C07D409/14;C07D413/06;C07D417/06;C07D473/10;(IPC1-7):A61K31/55;A61K31/50 |
主分类号 |
C07D295/06 |
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