| 摘要 |
Compounds which are acryloyl peptidic derivatives of formula (I), wherein n is 3 or 4; m is 0, 1 or 2; X and Y are the same or different and are selected, independently for each heterocyclic ring, from N or CH; R1 and R2, the same or different, are selected from hydrogen, halogen or C1-C4 alkyl; R3 is hydrogen or halogen, B is selected from the groups consisting of formulae (1), (2), (3), (4), (5), (6) and (7) wherein R4, R5, R7, and R8 are, independently from each other, hydrogen or C1-C4 alkyl; R6 is hydrogen, hydroxy or C1-C4 alkyl; or a pharmaceutically acceptable salt thereof; with the provisos that X and Y are not both N atoms for the same heterocyclic ring; when all of X and Y are CH groups and m is 0, then at least one of R4, R5, or R6 is other than hydrogen; when at least one of X and Y is other than CH, then at least one of R4 and R5 is other than hydrogen; are useful as antitumor agents. |
