NUCLEOPHOSMIN GENE HAVING ANTICANCER AGENT TOLERANCE AND THE USE THEREOF

摘要

PURPOSE: A nucleophosmin gene having anticancer agent tolerance and the use thereof are provided. The nucleophosmin gene is used for the diagnosis of anticancer agent tolerance and for the prescription of an anticancer agent optimized for a patient. CONSTITUTION: A nucleophosmin gene having anticancer agent tolerance has the nucleotide sequence of SEQ ID NO: 1. A method for screening a drug for overcoming the anticancer agent tolerance comprises the steps of: inserting the nucleophosmin gene of SEQ ID NO: 1 into a cancer cell and expressing it within the cancer cell; administrating an anticancer agent or an anticancer agent tolerance overcoming drug to the cancer cell; and analyzing proliferation of the cancer cell, wherein the cancer cell is a lung cancer cell or a stomach cancer cell; and the anticancer agent is selected from cisplatin, carboplatin, taxol, adriamycin, fluorouracil(5-FU), and etoposide(VP-16). A method for diagnosis of anticancer agent tolerance comprises analysis of expression of the nucleophosmin gene within the cancer cell.