Amphiphilic prodrugs

摘要

A prodrug comprises: (a) at least one therapeutic compound selected from etoposide or an etoposide analog which retains some or all of the therapeutic activity of etoposide and (b) one or more PEG polymers and/or oligomers, each joined to a bonding site on the therapeutic compound by a hydrolyzable bond. The PEG polymers and/or oligomers each comprise a straight or branched PEG segment consisting of 2 to 25 polyethylene glycol units and (ii) optionally comprising a salt-forming moiety.