| 摘要 |
A chimaeric adenovirus based on at least two different adenoviruses, whereby a cell-recognizing element of said chemaeric adenovirus is based on adenoviral material from a subgroup D and/or F adenovirus, which material confers the capability of infecting CAR negative cells, said chimaeric adenovirus further comprising an element from adenovirus 35 or a functional equivalent thereof, responsible for at least partially avoiding an immune response against adenovirus 35 or said functional equivalent, said functional equivalent being an adenovirus, which encounters pre-existing immunity in less than about 10% of the hosts to which it is administered for the first time. |
