BICYCLIC PYRROLYL AMIDES AS GLUCOGEN PHOSPHORYLASE INHIBITORS

摘要

Heterocyclic amide derivatives, of formula wherein -X-Y-Z is selected from -S-CR4=CR5-, -CR4=CR5-S-, -O-CR4=CR5-, -CR4=CR5-O-, -N-CR4-S-, -S-CR4-N-, -NR6-CR4=CR5- and -CR4=CR5-NR6-, or a pharmaceutically acceptable salts of an in vivo hydrolysable ester thereof, having glycogen phosphorylase inhibition activity. The derivatives are useful in the treatment of morbid conditions related to increased glycogen phosphorylase activity. Processes for the manufacture of said heterocyclic amide derivatives and pharmaceutical compositions containing them are described. 9 claims