| 发明名称 |
STABILIZED INTERFERON COMPOSITIONS |
| 摘要 |
<p>Stabilized pharmaceutical formulations comprising IFN-beta and highly purified mannitol are provided. The highly purified mannitol stabilizes the compositions by reducing the formation of IFN-beta adducts in comparison with IFN-beta formulated with mannitol that has not been highly purified. Methods for increase the stability of IFN-beta or a variant thereof in a liquid of lyophilized compositions and for increasing storage stability of such a composition are also provided. 40 claims</p> |
| 申请公布号 |
BG107887(A) |
申请公布日期 |
2004.01.30 |
| 申请号 |
BG20030107887D |
申请日期 |
2003.06.06 |
| 申请人 |
CHIRON CORPORATION |
发明人 |
WOLFE, SIDNEY N.;HORA, MANINDER S. |
| 分类号 |
A61M5/28;A61K9/00;A61K9/08;A61K9/19;A61K38/00;A61K38/21;A61K47/02;A61K47/26;A61K47/42;(IPC1-7):A61K38/21 |
主分类号 |
A61M5/28 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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