PEPTIDES AND PEPTIDE DERIVATIVES FOR THE TREATMENT OF alpha-SYNUCLEIN-RELATED DISEASES

摘要

The invention provides peptides which comprise a sequence of three to twelve contiguous amino acid residues (the "contiguous sequence") from amino acid residues 61 to 100 of naturally occurring alpha-synuclein. The contiguous sequence is linked at its N-terminal and/or C-terminal end to one or more further amino acid residue(s) which are more hydrophilic than the amino acid residue to which that end of the sequence is linked in naturally occurring alpha-synuclein. The invention also provides derivatives and analogues of such peptides. Peptides, derivatives or analogues of the invention are of use in prevention of alpha-synuclein oligomerisation and/or aggregation associated with the diseases known as the synucleinopathies. As a result peptides according to the invention are susceptible of use in the preparation of medicaments, and also in methods of treatment, for prevention and/or treatment of synucleinopathies.