发明名称 |
METHODS FOR DETECTING DEANTIGENIZED T CELL EPITOPES AND USES THEREOF |
摘要 |
<p>The present invention encompasses a novel approach to develop modified proteins that induce a reduced (or no) immune response (compared to an unmodified protein) in an animal, wherein one or more T cell epitope sequences present in the unmodified protein is/are replaced with one or more "deantigenized" T cell epitope sequences, which exhibit reduced or no binding to a MHC molecule (compared to the T cell epitope); thereby hindering the cellular process of immune response. The present invention provides a novel method for detecting deantigenized T cell epitopes and further reducing or eliminating immunogenicity of an otherwise immunogenic protein by substituting one or more deantigenized T cell epitope sequences for one or more T cell epitope sequences of the parent immunogenic polypeptide.</p> |
申请公布号 |
WO2004009109(A1) |
申请公布日期 |
2004.01.29 |
申请号 |
WO2003US23178 |
申请日期 |
2003.07.23 |
申请人 |
ABBOTT GMBH & CO. KG;BANERJEE, SUBHASHIS |
发明人 |
BANERJEE, SUBHASHIS |
分类号 |
C07K16/00;C07K16/24;G01N33/569;(IPC1-7):A61K38/04;C12N15/09;A61K39/395;C12N15/00 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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