发明名称 |
Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors |
摘要 |
The present invention provides methods for identifying an agent that specifically binds and/or modulates one topology of a chemokine receptor but not a second topology of the receptor. Such agents are useful as therapeutics for diseases or conditions associated with a particular chemokine receptor topology. Moreover, the agents are useful for detecting a particular topology of a chemokine receptor, thereby diagnosing disease or predisposition for a disease. In addition, the agents are useful for identifying and isolating cells that express a particular topology of a chemokine receptor.
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申请公布号 |
US2004018563(A1) |
申请公布日期 |
2004.01.29 |
申请号 |
US20030452015 |
申请日期 |
2003.05.30 |
申请人 |
CHEMOCENTRYX INC. |
发明人 |
BURNS JENNIFER M.;MIAO ZHENHUA;WEI ZHENG;HOWARD MAUREEN C.;PREMACK BRETT A.;SCHALL THOMAS J. |
分类号 |
C12N;G01N33/68;(IPC1-7):G01N33/53;C07K14/52 |
主分类号 |
C12N |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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