发明名称 |
Novel hedgehog-derived polypeptides |
摘要 |
The present invention provides two novel polypeptides, referred to as the "N" and "C" fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G<↓>CF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described.
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申请公布号 |
US2004018979(A1) |
申请公布日期 |
2004.01.29 |
申请号 |
US20030460594 |
申请日期 |
2003.06.11 |
申请人 |
BEACHY PHILIP A.;PORTER JEFFREY A. |
发明人 |
BEACHY PHILIP A.;PORTER JEFFREY A. |
分类号 |
A61K38/00;C07K14/435;C07K14/46;C07K14/47;C12N15/62;G01N33/68;G01N33/92;(IPC1-7):A61K38/17 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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