Control of protein systemic delivery by hypoxia using a tet-HIF1-alpha chimeric transactivator

摘要

An isolated polynucleotide which codes for a domain of a transcription factor, where the domain confers to the transcription factor susceptibility to degredation under normoxia conditions. Also provided is a chimeric transactivator containing such a domain and to polynucleotides and vectors which code for the same. A method of expressing a target gene in a subject invloving the use of such a chimeric transactivator is also provided. In particular, such a method can be used to increase the number of red blood cells or blood vessels in the subject.