发明名称 |
In vitro evolution of functional RNA and DNA using electrophoretic selection |
摘要 |
The CE-SELEX procedure of the present invention is a novel selection procedure that utilizes capillary electrophoresis (CE) in combination with conventional SELEX selection procedures. CE-SELEX, for the first time, allows selection to be performed in free solution. Performing selection against a target in free solution yields aptamers with improved affinity and/or improved selectivity toward target molecules for use as improved pharmaceuticals and diagnostic agents.
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申请公布号 |
US2004018530(A1) |
申请公布日期 |
2004.01.29 |
申请号 |
US20030448250 |
申请日期 |
2003.09.29 |
申请人 |
BOWSER MICHAEL T.;MENDONSA SHAUN D. |
发明人 |
BOWSER MICHAEL T.;MENDONSA SHAUN D. |
分类号 |
C12Q1/68;(IPC1-7):C12Q1/70;C12P19/34 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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