发明名称 |
COMPOSITION FOR SOLUBILIZATION OF PACLITAXEL AND PREPARATIONMETHOD THEREOF |
摘要 |
The present invention relates to a paclitaxel composition and the preparatio n methods thereof to solubilize paclitaxel wherein said composition comprises 4~90% by weight of at least one selected from the monoglycerides, 0.01~90% b y weight of at least one oil and 0.01~20% by weight of paclitaxel. Also the present invention relates to a paclitaxel composition including emulsifiers and the preparation methods thereof to solubilize paclitaxel wherein said composition comprises 4~90% by weight of at least one selected from the monoglycerides, 0.01~90% by weight of at least one oil, 0.01~90% by weight o f at least one emulsifier and 0.01~20% by weight of paclitaxel. The compositio n of the present invention is an effective paclitaxel delivery system since th e composition solubilizes paclitaxel, does not form aggregates after being dispersed in water, adsorbs well on the intestinal wall, and therefore has high bioavailability.
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申请公布号 |
CA2493336(A1) |
申请公布日期 |
2004.01.29 |
申请号 |
CA20032493336 |
申请日期 |
2003.07.18 |
申请人 |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY |
发明人 |
CHUNG, JIN-WOOK;CHUNG, HESSON;JEONG, SEO-YOUNG;PARK, JAE-HYUNG;CHOI, YOUNG-WOOK;YUK, SOON-HONG;KWON, ICK-CHAN;PARK, YEONG-TAEK;LEE, IN-HYUN |
分类号 |
A61K9/08;A61K9/00;A61K31/275;A61K31/337;A61K31/343;A61K31/4375;A61K31/439;A61K31/4422;A61K31/498;A61K31/513;A61K31/541;A61K31/555;A61K31/56;A61K31/65;A61K31/7048;A61K45/06;A61K47/10;A61K47/12;A61K47/14;A61K47/22;A61K47/36;A61K47/44;A61P35/00;(IPC1-7):A61K31/337 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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