METHODS AND COMPOSITIONS FOR ACTIVATING OR INHIBITING VEGF-D AND VEGF-C
摘要
Methods for activating endothelial growth factors VEGF-C or VEGF-D with plasmin, and methods of treatment comprising administering a pharmaceutical compositions comprising plasmin. Also disclosed are methods of screening for inhibitors of activation of the growth factors by plasmin, and method of treatment by blocking activation of VEGF-C/D activation by plasmin. Further disclosed are methods for screening for other proteases that activate VEGF-CD, and for inhibitors of such activation. The invention further includes inhibitors of plasmin activity and methods of treating patients in need thereof with said inhibitors.
申请公布号
WO2004009773(A2)
申请公布日期
2004.01.29
申请号
WO2003US22521
申请日期
2003.07.21
申请人
LUDWIG INSTITUTE FOR CANCER RESEARCH;MCCOLL, BRADLEY;BALDWIN, MEGAN;STACKER, STEVEN;ACHEN, MARC
发明人
MCCOLL, BRADLEY;BALDWIN, MEGAN;STACKER, STEVEN;ACHEN, MARC