| 发明名称 |
PIPERIDINE DERIVATIVES AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1ALPHA BINDING TO ITS RECEPTOR CCR1 |
| 摘要 |
<p>A compound of the formula (I) wherein a, b, c R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, Q, W, Y, and Z are defined as above , useful as potent and selective inhibitors of MIP-1alpha (CCL3) binding to its receptor CCR1 found on inflammatory and immunomodulatory cells (preferably leukocytes and lymphocytes).</p> |
| 申请公布号 |
WO2004009550(A1) |
申请公布日期 |
2004.01.29 |
| 申请号 |
WO2003IB02876 |
申请日期 |
2003.07.07 |
| 申请人 |
PFIZER PRODUCTS INC.;BLUMBERG, LAURA, COOK;BROWN, MATTHEW, FRANK;HAYWARD, MATTHEW, MERRILL;POSS, CHRISTOPHER, STANLEY |
发明人 |
BLUMBERG, LAURA, COOK;BROWN, MATTHEW, FRANK;HAYWARD, MATTHEW, MERRILL;POSS, CHRISTOPHER, STANLEY |
| 分类号 |
C07D211/14;A61K;A61K31/4409;A61K31/445;A61P3/00;A61P9/00;A61P9/10;A61P11/00;A61P25/00;A61P25/28;A61P29/00;A61P31/12;A61P35/00;A61P37/06;A61P37/08;A61P43/00;C07D;C07D211/46;(IPC1-7):C07D211/46 |
主分类号 |
C07D211/14 |
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