COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF ANGIOGENESIS
摘要
RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt1 and Flk-l/KDR inhibit expression of these genes. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.
申请公布号
WO2004009769(A2)
申请公布日期
2004.01.29
申请号
WO2003US22444
申请日期
2003.07.18
申请人
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;TOLENTINO, MICHAEL, J..;REICH, SAMUEL, JOTHAM