The present invention relates to immunogenic compositions for stimulating T cell proliferation and methods for enhancing therapeutic effectiveness of some traditional anti-cancer treatments. Specifically, local delivery of cytokines that target the plasma membrane of a cancerous cell exhibit more potent anti-tumor effects than systemic delivery of cytokines in soluble form. Figure 2 shows pulmonary metastasis images of untreated tumor cells with tumor cells treated with soluble IL-2 and tumor cells treated with GPI anchored IL-2.
