发明名称 |
NOVEL Notch-ORIGIN POLYPEPTIDES AND BIOMARKERS AND REAGENTS USING THE SAME |
摘要 |
<p>It is intended to provide extracellular markers whereby Notch signal transduction can be detected. Polypeptides (Nbeta), which are novel peptides originating in Notch protein and released form cells in the step of the nuclear migration of NICH (Notch intracellular cytoplasmic domain) due to the extracellular digestion and the subsequent protein digestion in the membrane during a series of the Notch protein digestion, are referred to as markers. These peptides (Nbeta) are released from the cells in proportion to the Notch signal depending on presenilin. By detecting these peptides, the Notch signal transduction, cell differentiation, cell tumorigenesis, apoptosis, Alzheimer's disease, etc. can be monitored.</p> |
申请公布号 |
WO2004009617(A1) |
申请公布日期 |
2004.01.29 |
申请号 |
WO2003JP09059 |
申请日期 |
2003.07.17 |
申请人 |
OSAKA INDUSTRIAL PROMOTION ORGANIZATION;OKOCHI, MASAYASU;TAKEDA, MASATOSHI |
发明人 |
OKOCHI, MASAYASU;TAKEDA, MASATOSHI |
分类号 |
C07K14/705;C12N1/15;C12N1/19;C12N1/21;C12N15/12;G01N33/68;(IPC1-7):C07K7/08;C07K16/18;G01N33/563;C12N5/10;C07K14/47 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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