APOPTOGENIC-BACTERIOCINS COMBINING BROAD SPECTRUM ANTIBIOTIC AND SELECTIVE ANTI-TUMORAL ACTIVITIES, AND COMPOSITIONS AND USES THEREOF

摘要

The present invention relates generally to bacterial proteins, particularly to . apoptogenic-bacteriocins, which are capable of killing other bacteria and of also inducing apoptosis in certain eukaryotic cells. The apoptogenic-bacteriocin of the present invention produces apoptosis in tumor-derived cells or cancer cells, while being not cytotoxic to normal cells and not inducing any evident toxicity in vivo in normal animals. Uses of the apoptogenic-bacteriocin and methods of treating cancer, tumors and other diseases of aberrant cell growth are provided.