发明名称 METHOD FOR PRODUCING 2-(-5-(4-FLUOROPHENYL)-3-PYRIDYLMETHYLAMINOMETHYL)-CHROMANE
摘要 The present invention relates to a process for the preparation of 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman, the enantiomers and its salts, characterised in that 5-(4-fluorophenyl)pyridine-3-carbaldehyde is reacted directly with aminomethylchroman or its salts under reducing conditions to give 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman, and the latter is, if desired, converted into one of its physiologically acceptable salts by treatment with an acid.
申请公布号 EP1383763(A2) 申请公布日期 2004.01.28
申请号 EP20020727539 申请日期 2002.04.08
申请人 MERCK PATENT GMBH 发明人 BOKEL, HEINZ-HERMANN;NEUNFELD, STEFFEN;GANTZERT, LUDWIG;KNIERIEME, RALF;SIMON, ELKE;DEVANT, RALF;HELM, UDO;REUBOLD, HELMUT
分类号 C07D311/58;C07D405/12;(IPC1-7):C07D405/12 主分类号 C07D311/58
代理机构 代理人
主权项
地址