发明名称 |
Production method of (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid and intermediate thereof |
摘要 |
The present invention relates to a production method of (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid which comprises optical resolution of racemic 3-hydroxy-3-(2-phenylethyl)hexanoic acid with an optically active amine of the formula (VIII)wherein R<2 >is 3,4-dimethoxyphenyl or 2-chlorophenyl. According to the present invention, (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid useful as a starting material of a pharmaceutical agent can be efficiently produced with a high optical purity and a relatively high total yield.
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申请公布号 |
US6683207(B2) |
申请公布日期 |
2004.01.27 |
申请号 |
US20020320325 |
申请日期 |
2002.12.16 |
申请人 |
SUMIKA FINE CHEMICALS CO., LTD. |
发明人 |
TANAKA MASAHIDE;MATSUI KOZO;KATSURA TADASHI;IWASAKI MITSUHIRO;MAEDA HIROSHI;ITAYA NOBUSHIGE |
分类号 |
C07C45/62;C07C45/73;C07C45/74;C07C49/213;C07C51/43;C07C51/487;C07C69/732;C07C211/29;C07C217/58;(IPC1-7):C07C59/48 |
主分类号 |
C07C45/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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