发明名称 |
Chlorohydroxyacetone derivative and process for producing optically active chloropropanediol derivative from the same |
摘要 |
A process for efficiently preparing an optically active chloropropanediol derivative, especially (S)-1-benzyloxy-3-chloro-2-propanol, which has a high optical purity and is useful as an intermediate for medicines. The process comprises treating an inexpensive racemic chloropropanediol derivative with a nitroxyl compound and an oxidizing agent to convert it into a chlorohydroxyacetone derivative and then stereospecifically reducing the carbonyl group of the chlorohydroxyacetone derivative by the action of either a carbonyl-reducing enzyme having the ability to stereospecifically reduce the chlorohydroxyacetone derivative or an optically treated culture of a microorganism having the ability to yield the carbonyl-reducing enzyme. Thus, an optically active chloropropanediol derivative is prepared.
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申请公布号 |
US6682916(B2) |
申请公布日期 |
2004.01.27 |
申请号 |
US20020069105 |
申请日期 |
2002.02.26 |
申请人 |
KANEKA CORPORATION |
发明人 |
TAOKA NAOAKI;MAEDA HIRONOBU;OKURO KAZUMI;TOYOTA KOICHIRO;YASOHARA YOSHIHIKO |
分类号 |
C07C45/29;C07C49/255;C12P7/04;C12P7/18;C12P7/26;C12P41/00;(IPC1-7):F12P7/18;C12P1/02 |
主分类号 |
C07C45/29 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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