发明名称 |
PHARMACEUTICAL COMPOSITION CONTAINING CHELIDONINE OR DERIVATIVES THEREOF |
摘要 |
PURPOSE: Provided is a pharmaceutical composition which effectively intercepts the passage of K+ mainly manifested in the atrium of the human body and is used for the treatment of the arrhythmia. CONSTITUTION: A pharmaceutical composition comprises chelidonine represented by the formula 1, derivatives thereof, and pharmaceutically acceptable carriers. In the formula 1, R1 is selected from the group consisting of hydrogen, hydroxy, lower alkoxy with 1-5 carbons, benzyloxy, lower alkylcarbonyloxy with 1-5 carbons, benzoyloxy, lower alkylsulphonyloxy with 1-5 carbons, arylsulphonyloxy, diphenylphosphonyloxy group and OCONH2 group, R2 is hydrogen or methyl group, and R3, R4 and R5 are hydrogen; or R1 forms a double bond with R2 or R3, R2 forms a double bond with R3, or R5 forms a double bond with neighboring N.
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申请公布号 |
KR20040007539(A) |
申请公布日期 |
2004.01.24 |
申请号 |
KR20037014400 |
申请日期 |
2003.11.05 |
申请人 |
CHAE, SOO WAN;EUN, JAE SOON;JUNG, YOUNG HOON;KIM, DAE KEUN;KWAK, YONG GEUN;ZEE, OK PYO |
发明人 |
CHAE, SOO WAN;EUN, JAE SOON;KIM, DAE KEUN;KWAK, YONG GEUN |
分类号 |
C07D491/153;A61K9/00;A61K9/08;A61K9/20;A61K9/48;A61K31/4355;A61K31/4741;A61K31/58;A61K47/26;A61P9/06;C07J71/00;(IPC1-7):A61K31/435 |
主分类号 |
C07D491/153 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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