THE USE OF SPECIFIED TCF TARGET GENES TO IDENTIFY DRUGS FOR THE TREATMENT OF CANCER, IN PARTICULAR COLORECTAL CANCER, IN WHICH TCF/Beta-CATENIN/WNT SIGNALLING PLAYS A CENTRAL ROLE

摘要

The present invention relates to the use of inhibitors of the expressed proteins of TCF target genes whose expression is regulated by TCF/ beta -catenin complexes for the preparation of a therapeutical composition for the treatment of cancers in which TCF/ beta -catenin signaling is deregulated. Such inhibitors can be antibodies, small molecules, antisense RNA and dsRNA for use in RNAi. The invention also relates to these inhibitors per se.