发明名称 |
Chimeric mouse having immunity constructed by using human cd34-positive cells and use thereof |
摘要 |
Chimeric mice were constructed by transferring human CD34<+ >cells (hematopoietic stem cells) into a SCID mouse. In these chimeric mice, hematopoietic stem cells persistently differentiated into immune cells. Consequently, the chimeric mice can be immunized over a long time and enable one to obtain human antibodies against arbitrary antigens containing a human self-component.
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申请公布号 |
US2004016007(A1) |
申请公布日期 |
2004.01.22 |
申请号 |
US20030276572 |
申请日期 |
2003.06.27 |
申请人 |
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发明人 |
HABU SONOKO;ANDO KIYOSHI;HOTTA TOMOMITSU |
分类号 |
A01K67/027;C07K16/00;C07K16/28;C07K16/44;C12N15/85;C12P21/08;(IPC1-7):A01K67/027 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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