发明名称 |
Methods and compositions related to IRM compounds and toll-like recptor pathways |
摘要 |
Methods for identifying a compound that activates a TLR-mediated cellular signaling pathway is disclosed. The method includes (a) exposing a TLR-positive cell culture to a test compound and measuring a TLR-mediated cellular response; (b) exposing a TLR-negative cell culture to a test compound and measuring a TLR-mediated cellular response; and (c) identifying the test compound as an IRM if the cellular response in the TLR-positive cell culture is greater than the cellular response of the TLR-negative cell culture. Methods of eliciting a TLR-mediated cellular response are also disclosed. Such methods include administration of an IRM compound to an IRM-responsive cell so that the IRM compounds affects at least one TLR-mediate cellular signaling pathway.
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申请公布号 |
US2004014779(A1) |
申请公布日期 |
2004.01.22 |
申请号 |
US20020294935 |
申请日期 |
2002.11.14 |
申请人 |
3M INNOVATIVE PROPERTIES COMPANY |
发明人 |
GORDEN KEITH B.;QIU XIAOHONG;TOMAI MARK A.;VASILAKOS JOHN P. |
分类号 |
G01N33/50;A61K31/00;A61K31/4745;A61K45/00;A61P11/02;A61P11/06;A61P17/04;A61P31/00;A61P31/04;A61P31/12;A61P35/00;A61P37/08;A61P43/00;C07D471/04;C12N15/09;C12Q1/02;G01N33/15;G01N33/68;(IPC1-7):A61K31/474 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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