| 发明名称 |
Targeted chromosomal genomic alterations with modified single stranded oligonucleotides |
| 摘要 |
Presented are methods and compositions for targeted chromosomal genomic alterations using modified single-stranded oligonucleotides of the invention have at least one modified nuclease-resistant terminal region comprising phosphorothioate linkages, LNA analogs or 2'-O-Me base analogs.
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| 申请公布号 |
US2004014057(A1) |
申请公布日期 |
2004.01.22 |
| 申请号 |
US20020261185 |
申请日期 |
2002.09.27 |
| 申请人 |
KMIEC ERIC B.;GAMPER HOWARD B.;RICE MICHAEL C. |
发明人 |
KMIEC ERIC B.;GAMPER HOWARD B.;RICE MICHAEL C. |
| 分类号 |
C12N15/09;A61K31/7088;A61K31/712;A61K31/7125;A61K38/00;A61K48/00;A61P1/16;A61P3/06;A61P7/04;A61P7/06;A61P25/28;A61P35/00;A61P43/00;C12N5/10;C12N15/10;C12N15/113;C12Q1/68;(IPC1-7):A61K48/00;C07H21/04 |
主分类号 |
C12N15/09 |
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