ALTERED INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS

摘要

Altered IGFBPs are able to bind IGF but the release is inhibited by resistan ce to protease cleavage and/or reduced binding to extracellular matrix (ECM). Alterations have been made in IGFBP-2 to the linker domain in particular and two amino acid motifs found to be important for ECM binding. IGF-1 mediated proliferation of cancer cells have been inhibited by the use of these altere d IGFBPs.