VARIANT POLYNUCLEOTIDE AND NUCLEIC ACID MOLECULE WHICH CAN BE USED FOR GENETIC DIAGNOSIS OF MEDICINE ABSORPTION ABNORMALITY IN WHICH ABCG2 PROTEIN PARTICIPATE

摘要

PROBLEM TO BE SOLVED: To provide a nucleic acid probe used for the genetic diagnosis of a medicine absorption abnormality in which ABCG2 protein participates, and to provide a primer.

SOLUTION: This nucleic acid molecule which can detect a mutation that a codon encoding the glutamine residue at the 126-position of the ABCG2 protein is changed into a termination codon, in the ABCG2 gene, contains a nucleotide fragment capable of being hybridized by a polynucleotide or its complementary polynucleotide. The polynucleotide encodes a protein containing a specific amino acid sequence and has the mutation that the codon encoding the glutamine residue of the 126-position of the ABCG2 protein is changed into the termination codon.

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