发明名称 |
COMPOSITIONS AND METHODS TO PREVENT METASTASIS FROM PRIMARY MALIGNANCIES |
摘要 |
We have now discovered a new method for treating carcinoembriyonic antigen (CEA) associated cancers. This involves blocking a protein expressed by the hnRNP M4 gene (preferably the human hnRNP M4 gene). We identified and isolated a liver-derived recombinant cDNA clone, termed heterogeneous nuclear RNA binding protein M4 (hnRNP M4) SEQ ID NO: 1, from rat macrophages Kupffer cells (KC) that encodes a novel protein interacting with CEA molecules and is 91% homologous with the deletion mutant of the human hnRNP M4 gene (# U32577). The novel protein is, hereinafter, considered as one protein population with the human homologue and referred to herein as hnRNP M4 CEA receptor, or hnRNP M4. |
申请公布号 |
WO02076389(A3) |
申请公布日期 |
2004.01.22 |
申请号 |
WO2002US08569 |
申请日期 |
2002.03.21 |
申请人 |
THE TRUSTEES OF BOSTON UNIVERSITY;THOMAS, PETER;BAJENOVA, OLGA |
发明人 |
THOMAS, PETER;BAJENOVA, OLGA |
分类号 |
A61K38/00;A61P35/00;C07K14/47;C07K14/705;C12N15/12;C12P21/08 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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