发明名称 |
MESOTHELIN VACCINES AND MODEL SYSTEMS |
摘要 |
Mesothelin can be used as an immunotherapeutic target. It induces a cytolyti c T cell response. Portions of mesothelin which induce such responses are identified. Vaccines can be either polynucleotide- or polypeptide-based. Carriers for raising a cytolytic T cell response include bacteria and viruse s. A mouse model for testing vaccines and other anti-tumor therapeutics and prophylactics comprises a strongly mesothelin-expressing, transformed peritoneal cell line.
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申请公布号 |
CA2492160(A1) |
申请公布日期 |
2004.01.22 |
申请号 |
CA20032492160 |
申请日期 |
2003.07.14 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
WU, TZYY-CHOOU;HUNG, CHIEN-FU;JAFFEE, ELIZABETH;HRUBAN, RALPH |
分类号 |
A61K39/00;(IPC1-7):C12N15/62;A61K48/00;A61K31/708;C07K14/705;C07K19/00;A61P35/00;C12Q1/00;A61K39/02;C12Q1/02;C07K7/06;C12N5/06;A61K38/08;C07K7/08;C12N5/10;C12N15/11;C12N15/12;A61K38/17;C07K16/28 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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