发明名称 |
Specificity in treatment of diseases |
摘要 |
A drug is modified by covalently coupling a blocking group to the drug via a nitrogen atom in the blocking group. The blocking group in the modified drug prevents metabolic conversion and sequestration of the drug in non-target cells, and the blocking group is enzymatically removed in the target cell. Particularly contemplated advantages of presented compounds and methods include reduction of cytotoxicity by inhibition of metabolic conversion to potentially cytotoxic metabolites, reduction of dosages of drugs by reduction of sequestration into non-target cells, and increase of selectivity of a drug.
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申请公布号 |
US2004014696(A1) |
申请公布日期 |
2004.01.22 |
申请号 |
US20030343529 |
申请日期 |
2003.07.11 |
申请人 |
LAU JOHNSON;HONG ZHI;LIN CHIN-CHUNG |
发明人 |
LAU JOHNSON;HONG ZHI;LIN CHIN-CHUNG |
分类号 |
A61K31/52;A61K31/7056;C07H19/056;(IPC1-7):A61K31/705 |
主分类号 |
A61K31/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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