ARYL PIPERIDINE DERIVATIVES AS INDUCERS OF LDL-RECEPTOR EXPRESSION FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA

摘要

This invention relates to novel compounds which up-regulate LDL receptor (LDL-r) expression and to processes for their preparation, pharmaceutical compositions containing them and their medical use. More particularly, this invention relates to novel aromatic piperidines of formula (I) and their use in therapy. wherein Ar1is substituted by at least one R' group selected from: -O(CR<a>R<b>)nC(O)NRxRy,. -O(CH2)nCN, -O(CH2)nO(CH2)mOR<2>, -O(CH2)nCO2R<2>, -OSO2NRXRy, -OSO2(CH2)pCH3, -(CR<a>R<b>)nC(O)NRXRy, -(CH2)nCN, -(CH2)nO(CH2)mOR<2>, -(CH2)nCO2R<2>, -(CH2)nC(O)R<2>, - SO2NRXRy, -SO2(CH2)pCH3, -CH=CHC(O)NRxRy, -CH=CHCN, -CH=CHCO2R<2>, -CO2R<2> , - C(O)R<2>, -C(O)NRXRy and C2-5alkenyl; and Ar2 is substituted by 1-4 groups independently selected from the group consisting of: (CH2)nOH and -C02(CH2)pCH3.