| 摘要 |
The invention is in the field of immunogenicity. In one embodiment, the invention relates to method of identifying T-cell epitopes in amyloid beta peptide or homologue thereof. In another embodiment, the invention relates t o a vaccine comprising an amyloid beta peptide or homologue thereof, whereby t he selected peptide is a peptide which lacks certain T-cell epitopes or a pepti de which is modified by deleting or modifying amino acids so as to reduce ox eliminate the T-cell epitopes. The selected peptides are further assessed fo r reduced capacity to form fibrils, reduced cytotoxicity, and a reduced abilit y to induce a cellular autoimmune response. The selected peptides are further assessed for ability to induce a humoral immune response. In another embodiment, the invention relates to a method of predicting the reaction of an individual to a vaccine, which comprises amyloid beta peptide or homologue thereof, based on the HLA haplotype of the subject. In another embodiment, t he invention provides a method for matching a vaccine comprising arnyloid beta peptide or homologue thereof to an individual, based on the HI,A haplotype o f that individual. In another embodiment, the invention provides a vaccine comprising an amyloid beta peptide or homologue thereof, whereby the arnyloi d beta peptide or homologue thereof, lacks the ability to induce a T-cell response.
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