| 摘要 |
PROBLEM TO BE SOLVED: To provide a method having reliability and high sensibility, being simple and low-priced and capable of promptly judging for hormone action of a material. SOLUTION: The method for assaying the hormone action of material, especially an androgen action or an antiandrogenic activity, is disclosed. The method comprises (a) exposing to the material a cell transformed by two vectors in which one vector contains a DNA encoding a nuclear receptor protein or a fragment thereof and another vector contains a DNA encoding comodulator FOXG1C or a fragment thereof and (b) measuring a transcriptional activity caused by the nuclear receptor or the fragment thereof in the presence of the comodulator or the fragment thereof and/or measuring influence of the material on the interaction between the receptor or the fragment thereof and the comodulator or the fragment thereof by the interaction of protein-protein or protein-protein-DNA. In addition, a trouble of comodulation mechanism between an androgen receptor and FOXG1C is provided. COPYRIGHT: (C)2004,JPO
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