Mesothelin can be used as an immunotherapeutic target. It induces a cytolytic T cell response. Portions of mesothelin which induce such responses are identified. Vaccines can be either polynucleotide- or polypeptide-based. Carriers for raising a cytolytic T cell response include bacteria and viruses. A mouse model for testing vaccines and other anti-tumor therapeutics and prophylactics comprises a strongly mesothelin-expressing, transformed peritoneal cell line.
申请公布号
WO2004006837(A2)
申请公布日期
2004.01.22
申请号
WO2003US21643
申请日期
2003.07.14
申请人
THE JOHNS HOPKINS UNIVERSITY;JAFFEE, ELIZABETH;WU, TZYY-CHOOU;HUNG, CHIEN-FU;HRUBAN, RALPH
发明人
JAFFEE, ELIZABETH;WU, TZYY-CHOOU;HUNG, CHIEN-FU;HRUBAN, RALPH