PROTEOMIC SCREEN TO IDENTIFY DISEASE-RELATED BIOLOGICAL MOLECULES AND INHIBITORS THERETO

摘要

The invention provides a new paradigm for a screening method by combining the biochemical approach of specific binding between a ligand and a target, e.g. an antibody and an antigen, with the genetic principle of a functional screen. The present invention demonstrates its utility for identifying novel disease-relevant proteins and inhibitory ligands, e.g. antibodies or antibody fragments, that may serve as therapeutic leads for a wide variety of diseases, whether the cause of the disease is derivable from a virus, a bacterium, a lower eukaryote or from a misregulation of the cells of the subject to be treated.