<p>A process for making paclitaxel comprises: (a) acetylating 10-deacetyl baccatin-III at the C-10 position in the presence of a tertiary amine base to give baccatin-III; (b) protecting baccatin-III at the C-7 position by reacting baccatin-III with a protecting group; (c) converting the product of step (b) to paclitaxel. Preferably, the protecting group at the C-7 position is 2,2,2-trichloroethylchloroformate.</p>
申请公布号
WO2004007473(A1)
申请公布日期
2004.01.22
申请号
WO2003GB03041
申请日期
2003.07.15
申请人
CIPLA LIMITED;RAO, DHARMARAJ, RAMACHANDRA;KANKAN, RAJENDRA, NARAYANRAO;WAIN, CHRISTOPHER, PAUL