发明名称 Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
摘要 Compounds represented by the formula: Wherein A is -(CH2)n-R, -CH=CH2, -CH2-CH=CH2, -O-(CH2)n-R, -CH(OH)CH3, -CH(OH)-CH2OH, -CH2-CH(OH)CH3, -CH2-CH(OH)-CH2OH, -CH(OH)-CH(OH)-CH3; R is H, OH, F, N3, NH2, CO2H, SH, alkyl, S-alkyl, O-acyl, CONH2, CONH-alkyl; Z and Z' independently is OR<1>, OR<2>, O-(CH2)n-O-alkyl or aminoacids and esters thereof; R<1 >and R<2 >independently is H, alkyl, aryl, pivaloyloxymethyl, phthalyl or substituted phthalyl, C(R<3>)2OC(O)X(R<4>)a, R<3 >is -H, C1-C12 alkyl, C5-C12 aryl, C2-C12 alkenyl, C2-C12 alkynyl, C7-C12 alkenylaryl, C7-C12 alkynylaryl, or C6-C12 alkaryl, any of which is unsubstituted or is substituted with 1 or 2 halo, cyano, azido, nitro, or -OR<5>; R<4 >is -H, C1-C12 alkyl, C5-C12 aryl, C2-C12 alkenyl, C2-C12 alkynyl, C7-C12 alkenylaryl, C7-C12 alkynylaryl, or C6-C12 alkaryl, any of which is unsubstituted or is substituted with 1 or 2 halo, cyano, azido, nitro, -N(R<6>)2 or -OR<5>; R<5 >is C1-C12 </subscri
申请公布号 US2004014722(A1) 申请公布日期 2004.01.22
申请号 US20030437179 申请日期 2003.05.14
申请人 BIOCRYST PHARMACEUTICALS, INC. 发明人 BABU YARLAGADDA S.;CHAND POORAN;EL-KATTAN YAHYA;WU MINWAN
分类号 A61K31/13;A61K31/575;A61K31/66;A61K31/662;A61K31/663;A61K31/704;A61K31/7056;A61K36/28;A61K38/20;A61K38/21;A61P31/14;A61P31/16;A61P31/20;A61P43/00;C07F9/10;C07F9/6512;C07F9/6561;(IPC1-7):A61K31/675;C07F9/651 主分类号 A61K31/13
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