发明名称 |
MUTATIONS OF VOLTAGE-GATED POTASSIUM CHANNELS |
摘要 |
The subject invention includes mutant voltage-gated ion channels that are op en over a wide range of potential differences across membranes. The present invention also includes methods of use of such mutant voltage-gated ion channels in cells with highly negative potential differences across their membranes. One preferred mutant voltage-gated ion channel is a channel with a mutation at the residue homologous to P513 in Kv1.5 and at least one mutatio n at one of the residues homologous to R400, R403, and R409 in Kv1.5.
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申请公布号 |
CA2492275(A1) |
申请公布日期 |
2004.01.22 |
申请号 |
CA20032492275 |
申请日期 |
2003.07.14 |
申请人 |
CARDIOME INC. |
发明人 |
STEELE, DAVID;FEDIDA, DAVID |
分类号 |
C07K14/705;C12N1/15;(IPC1-7):C12Q1/02;C07H21/04;C12N1/16;C07K14/39 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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